Original Article from The New England Journal of Medicine — Prevention of Corticosteroid Osteoporosis -- A Comparison of Calcium, Calcitriol, and Calcitonin Calcitriol, parathyroid hormone, and calcitonin regulate Calcium status. The main function of calcitriol is to increase the uptake absorption of calcium from the gut.Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid.
Calcitonin is a hormone that is produced in humans by the parafollicular cells (commonly known as C-cells) of the thyroid gland. Calcitonin is involved in helping to regulate levels of calcium and phosphate in the blood, opposing the action of parathyroid hormone . However, on further analysis, the incidence of hypercalcemia and/or Ca × P> 75 for two consecutive laboratory draws and the incidence of hypercalcemia and/or Ca × P> 75 for four consecutive laboratory draws was significantly lower in the paricalcitol group compared to the calcitriol group (18% vs. 33%) (P = 0.008). There was no difference in ... Mar 26, 2018 · Calcitonin is produced by small clusters of C cells (parafollicular cells), located in the thyroid gland in the walls of the much more conspicuous follicles that produce thyroid hormone.